ISOLATION AND CHARACTERIZATION OF THE DUOCARMYCIN ADENINE DNA ADDUCT

被引：121

作者：

BOGER, DL

ISHIZAKI, T

ZARRINMAYEH, H

机构：

[1] Contribution from the Department of Chemistry, Purdue University, West Lafayette

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 17期

关键词：

D O I：

10.1021/ja00017a042

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The isolation and full characterization of the duocarmycin-adenine adduct 7 derived from the duocarmycin alkylation of calf thymus DNA is detailed.

引用

页码：6645 / 6649

页数：5

共 18 条

[1] SEQUENCE-SPECIFIC CLEAVAGE OF DNA BY N-BROMOACETYLDISTAMYCIN - PRODUCT AND KINETIC ANALYSES
BAKER, BF
DERVAN, PB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (07) : 2700 - 2712
[2] SYNTHESIS AND PRELIMINARY EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065 DUOCARMYCIN COMMON PHARMACOPHORE
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) : 4499 - 4502
[3] DUOCARMYCIN PYRINDAMYCIN DNA ALKYLATION PROPERTIES AND IDENTIFICATION, SYNTHESIS, AND EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065-DUOCARMYCIN COMMON PHARMACOPHORE
BOGER, DL
ISHIZAKI, T
ZARRINMAYEH, H
MUNK, SA
KITOS, PA
SUNTORNWAT, O
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) : 8961 - 8971
[4] AN ALTERNATIVE AND CONVENIENT STRATEGY FOR GENERATION OF SUBSTANTIAL QUANTITIES OF SINGLY 5'-P-32-END-LABELED DOUBLE-STRANDED DNA FOR BINDING-STUDIES - DEVELOPMENT OF A PROTOCOL FOR EXAMINATION OF FUNCTIONAL FEATURES OF (+)-CC-1065 AND THE DUOCARMYCINS THAT CONTRIBUTE TO THEIR SEQUENCE-SELECTIVE DNA ALKYLATION PROPERTIES
BOGER, DL
MUNK, SA
ZARRINMAYEH, H
ISHIZAKI, T
HAUGHT, J
BINA, M
[J]. TETRAHEDRON, 1991, 47 (14-15) : 2661 - 2682
[5] DUOCARMYCIN A, 1988, J ANTIBIOT, V41, P1915
[6] REACTION OF THE ANTITUMOR ANTIBIOTIC CC-1065 WITH DNA - STRUCTURE OF A DNA ADDUCT WITH DNA-SEQUENCE SPECIFICITY
HURLEY, LH
REYNOLDS, VL
SWENSON, DH
PETZOLD, GL
SCAHILL, TA
[J]. SCIENCE, 1984, 226 (4676) : 843 - 844
[7] DC89-A1, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES
ICHIMURA, M
MUROI, K
ASANO, K
KAWAMOTO, I
TOMITA, F
MORIMOTO, M
NAKANO, H
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (09) : 1285 - 1288
[8] DUOCARMYCIN-SA, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES SP
ICHIMURA, M
OGAWA, T
TAKAHASHI, K
KOBAYASHI, E
KAWAMOTO, I
YASUZAWA, T
TAKAHASHI, I
NAKANO, H
[J]. JOURNAL OF ANTIBIOTICS, 1990, 43 (08) : 1037 - 1038
[9] ANTITUMOR-ACTIVITY OF PYRINDAMYCIN-A AND PYRINDAMYCIN-B
ISHII, S
NAGASAWA, M
KARIYA, Y
YAMAMOTO, H
INOUYE, S
KONDO, S
[J]. JOURNAL OF ANTIBIOTICS, 1989, 42 (11) : 1713 - 1717
[10] DETERMINATION OF THE MAJOR TAUTOMERIC FORM OF THE COVALENTLY MODIFIED ADENINE IN THE (+)-CC-1065 DNA ADDUCT BY H-1 AND N-15 NMR-STUDIES
LIN, CH
HURLEY, LH
[J]. BIOCHEMISTRY, 1990, 29 (41) : 9503 - 9507

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