AN AMINO-TERMINAL FRAGMENT OF SV40 T-ANTIGEN INDUCES CELLULAR DNA-SYNTHESIS IN QUIESCENT RAT-CELLS

被引：18

作者：

SOMPAYRAC, L

DANNA, KJ

机构：

[1] Department of Molecular, Cellular, Developmental Biology, University of Colorado, Boulder

来源：

VIROLOGY | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/viro.1994.1255

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SV40 large T antigen can stimulate cellular DNA synthesis in quiescent cells. Here we report that an SV40 mutant, which expresses only the amino-terminal 147 amino acids of this protein and which does not make small t antigen, stimulates cellular DNA synthesis in quiescent rat cells at levers similar to those achieved with serum stimulation. Thus, the amino-terminal 147 amino acids of large T antigen define a domain of this protein that is sufficient for efficient stimulation of cellular DNA synthesis in the absence of small t antigen. (C) 1994 academic Press, Inc.

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页码：849 / 853

页数：5

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