ELIMINATION OF GADOLINIUM-DTPA BY PERITONEAL-DIALYSIS

被引：21

作者：

DORSAM, J ^{[1
]}

KNOPP, MV ^{[1
]}

SCHAD, L ^{[1
]}

PIESCHE, S ^{[1
]}

CARL, S ^{[1
]}

OESINGMANN, N ^{[1
]}

机构：

[1] GERMAN CANC RES CTR,W-6900 HEIDELBERG,GERMANY

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 1995年 / 10卷 / 07期

关键词：

GOADLINIUM-DTPA; MAGNETIC RESONANCE IMAGING; PERITONEAL DIALYSIS; PHARMACOKINETICS;

D O I：

10.1093/ndt/10.7.1228

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Magnetic resonance urography (MRU) after i.v. injection of gadolinium-DTPA (0.1 mmol/kg bodyweight) was performed in a patient with transplant dysfunction after renal allograft transplantation. Renal replacement therapy was accomplished by means of peritoneal dialysis. Gadolinium-DTPA concentrations in urine and dialysate were measured repeatedly during a 48-h period with inductively coupled plasma atomic emission spectrometry. The total 24-h creatinine clearance was 10.8 ml/min on day 1 and 13.7 ml/min on day 2. The corresponding total gadolinium clearance was 12.8ml/min and 15.8ml/min respectively. Gadolinium-DTPA was removed from the body through peritoneal dialysis at a mean clearance rate of 5.13 ml/min. Plasma half-life of gadolinium-DTPA was prolonged to 9h. No side-effects due to gadolinium-DTPA were noted. MRU provided a better visualization of the morphology of the urinary tract than scintigraphic studies. By measuring the changes of signal intensity, the gadolinium excretion could be calculated.

引用

页码：1228 / 1230

页数：3

共 10 条

[1] CASE-REPORT - GADOPENTETATE DIMEGLUMINE ENHANCED MRI IN AN ANEPHRIC PATIENT ON DIALYSIS [J].