PHLOROGLUCINOL DERIVATIVES AS COMPETITIVE INHIBITORS AGAINST THROMBOXANE-A2 AND LEUKOTRIENE-D4 FROM HYPERICUM-ERECTUM

被引：34

作者：

TADA, M

CHIBA, K

YAMADA, H

MARUYAMA, H

机构：

[1] Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Fuchu, Tokyo

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 08期

关键词：

HYPERICUM-ERECTUM; HYPERICACEAE; ANTIALLERGY; THROMBOXANE-A2; LEUKOTRIENE-D4; PHLOROGLUCINOL; ANTIBACTERIAL COMPOUNDS;

D O I：

10.1016/0031-9422(91)85100-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New antibacterial phloroglucinol derivatives were isolated from Hypericum erectum. They showed marked antagonistic activity against both thromboxane A2 and leukotriene D4.

引用

页码：2559 / 2562

页数：4

共 10 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[2] STRUCTURE ELUCIDATION OF THE ANTIBIOTIC DESERTOMYCIN THROUGH THE USE OF NEW TWO-DIMENSIONAL NMR TECHNIQUES [J].

BAX, A ;

ASZALOS, A ;

DINYA, Z ;

SUDO, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (25) :8056-8063

[3]

BOLTE ML, 1984, AGR BIOL CHEM TOKYO, V48, P373, DOI 10.1080/00021369.1984.10866137

[4] NOVEL PHLOROGLUCINOLS FROM THE PLANT MELICOPE-SESSILIFLORA (RUTACEAE) [J].

CHAN, JA ;

SHULTIS, EA ;

CARR, SA ;

DEBROSSE, CW ;

EGGLESTON, DS ;

FRANCIS, TA ;

HYLAND, LJ ;

JOHNSON, WP ;

KILLMER, LB ;

STAIGER, DB ;

WESTLEY, JW .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (09) :2098-2103

[5]

MORRIS GA, 1980, J AM CHEM SOC, V102, P428, DOI 10.1021/ja00521a097

[6] ENHANCEMENT OF NUCLEAR MAGNETIC-RESONANCE SIGNALS BY POLARIZATION TRANSFER [J].

MORRIS, GA ;

FREEMAN, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (03) :760-762

[7] ANTIMICROBIAL COMPOUNDS, CHINESIN-I AND CHINESIN-II FROM FLOWERS OF HYPERICUM-CHINENSE L [J].

NAGAI, M ;

TADA, M .

CHEMISTRY LETTERS, 1987, (07) :1337-1340

[8] ANTIVIRAL AND ANTIMICROBIAL ACTIVITY OF 2,4-DIACYLPHLOROGLUCINOLS, 2-ACYLCYCLOHEXANE-1,3-DIONES AND 2-CARBOXAMIDOCYCLO-HEXANE-1,3-DIONES [J].

TADA, M ;

TAKAKUWA, T ;

NAGAI, M ;

YOSHII, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1990, 54 (11) :3061-3063

[9]

TAKASAKI M, 1990, CHEM PHARM BULL, V38, P1444, DOI 10.1248/cpb.38.1444

[10] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A SERIES OF CAESPITIN DERIVATIVES [J].

VANDERSCHYF, CJ ;

DEKKER, TG ;

FOURIE, TG ;

SNYCKERS, FO .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (03) :375-381

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