SPONTANEOUS DIABETES-MELLITUS - REVERSAL AND PREVENTION IN THE BB-W RAT WITH ANTISERUM TO RAT LYMPHOCYTES

被引：237

作者：

LIKE, AA

ROSSINI, AA

GUBERSKI, DL

APPEL, MC

WILLIAMS, RM

机构：

[1] UNIV MASSACHUSETTS,SCH MED,DEPT MED,WORCESTER,MA 01605

[2] NORTHWESTERN UNIV,DEPT MED,CHICAGO,IL 60611

来源：

SCIENCE | 1979年 / 206卷 / 4425期

关键词：

D O I：

10.1126/science.388619

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morphologic and physiologic characteristics of human insulin-dependent diabetes mellitus.

引用

页码：1421 / 1423

页数：3