THE PROTECTIVE EFFECT OF GAMMA-HYDROXYBUTYRATE IN REGIONAL INTESTINAL ISCHEMIA IN THE HAMSTER

被引：35

作者：

BOYD, AJ

SHERMAN, IA

SAIBIL, FG

MAMELAK, M

机构：

[1] SUNNYBROOK HLTH SCI CTR,ARON M RAPPAPORT MICROCIRCULAT LAB,R WING,2075 BAYVIEW AVE,TORONTO M4N 3M5,ONTARIO,CANADA

[2] UNIV TORONTO,INST BIOMED ENGN,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

GASTROENTEROLOGY | 1990年 / 99卷 / 03期

关键词：

D O I：

10.1016/0016-5085(90)90982-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The purpose of this study was to determine whether γ-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that was completely prevented by γ-hydroxybutyrate pretreatment. Naloxone partially blocked this protective effect. Allopurinol provided only partial protection against this injury, whereas vitamin E provided none. Treatment with γ-hydroxybutyrate after ischemia but before reperfusion also provided significant protection. This study clearly demonstrates that γ-hydroxybutyrate provides significant protection against intestinal ischemic injury and that it may do so via an opiate receptor-mediated mechanism. © 1990.

引用

页码：860 / 862

页数：3

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