HIBERNATION - OPIOID-DEPENDENT STATE

被引：56

作者：

MARGULES, DL ^{[1
]}

GOLDMAN, B ^{[1
]}

FINCK, A ^{[1
]}

机构：

[1] UNIV CONNECTICUT,DEPT BIOBEHAV SCI,STORRS,CT 06288

来源：

BRAIN RESEARCH BULLETIN | 1979年 / 4卷 / 06期

关键词：

Hibernation; Naloxone; Opiate peptides; Opioid-withdrawal syndrome;

D O I：

10.1016/0361-9230(79)90003-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hibernation reduces substantially the heart rate of hamsters as well as the respiratory rate, the body temperature and the arousal level. The heart rate is reversed dramatically by the injection of low doses of Naloxone and in some cases the hamster arouses prematurely from hibernation. The effect is not due to the pain of the injection because saline injections do not produce such changes. The effect requires a pre-existing state of hibernation because Naloxone has no cardioacceleratory or arousal effect in non-hibernating hamsters that have had their heart rate and body temperature decreased substantially during hypothermia. These results suggest that endogenous opioids may comtribute specifically to the state of hibernation. Moreover, a physiological role may exist for an anti-opioid system in the promotion of arousal from hibernation. © 1979.

引用

页码：721 / 724

页数：4

共 6 条

[1]

FADEN AJ, 1979, SCIENCE, V205, P315

[2]

FOLK GE, 1974, TXB ENV PHYSL, P279

[3]

HOLADAY VW, 1978, NATURE, V450, P275

[4]

LYMAN CHARLES P., 1965, HANDBOOK PHYSIOL, V3, P1967