SOME NOVEL INHIBITORS OF PORCINE PANCREATIC ELASTASE

被引：37

作者：

HASSALL, CH

JOHNSON, WH

ROBERTS, NA

机构：

[1] Roche Products Limited, Welwyn Garden City, Herts

来源：

BIOORGANIC CHEMISTRY | 1979年 / 8卷 / 03期

关键词：

D O I：

10.1016/0045-2068(79)90057-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New evidence has enabled the identification of novel specific inhibitors of porcine pancreatic elastase with potential for action in vivo. The basis for optimization of activity in this series of derivatives of alanylproline, and the relationship of elastase inhibition to the binding mode, is discussed. © 1979.

引用

页码：299 / 309

页数：11

共 42 条

[1] INACTIVATION OF SOME PANCREATIC AND LEUKOCYTE ELASTASES BY PEPTIDE CHLOROMETHYL KETONES AND ALKYL ISOCYANATES
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KOJ, A
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[2] ATLAS D, 1973, BIOCHEMISTRY-US, V12, P2573
[3] ACTIVE SITE OF ELASTASE - PARTIAL MAPPING BY MEANS OF SPECIFIC PEPTIDE SUBSTRATES
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[J]. JOURNAL OF MOLECULAR BIOLOGY, 1975, 93 (01) : 39 - &
[5] SPECIFICITY OF ELASTASE - HYDROLYSIS OF PEPTIDE PARANITROBENZYL ESTERS
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BERGER, A
[J]. BIOCHEMISTRY, 1972, 11 (25) : 4719 - +
[6] ALKYL ISOCYANATES AS ACTIVE-SITE-SPECIFIC REAGENTS FOR SERINE PROTEASES - REACTION PROPERTIES
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[J]. BIOCHEMISTRY, 1973, 12 (05) : 828 - 834
[7] ALKYL ISOCYANATES AS ACTIVE-SITE-SPECIFIC REAGENTS FOR SERINE PROTEASES - IDENTIFICATION OF ACTIVE-SITE SERINE AS SITE OF REACTION
BROWN, WE
WOLD, F
[J]. BIOCHEMISTRY, 1973, 12 (05) : 835 - 840
[8] TRIFLUOROACETYLATED PEPTIDES AS SUBSTRATES AND INHIBITORS OF ELASTASE - NUCLEAR MAGNETIC-RESONANCE STUDY
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LHOSTE, JM
[J]. BIOCHEMISTRY, 1976, 15 (10) : 2230 - 2236
[9] THE DETERMINATION OF ENZYME INHIBITOR CONSTANTS
DIXON, M
[J]. BIOCHEMICAL JOURNAL, 1953, 55 (01) : 170 - 171
[10] PROTEINASE-INHIBITORS .1. INHIBITORS OF ELASTASE
DORN, CP
ZIMMERMAN, M
YANG, SS
YUREWICZ, EC
ASHE, BM
FRANKSHUN, R
JONES, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (11) : 1464 - 1468

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