SOME NOVEL INHIBITORS OF PORCINE PANCREATIC ELASTASE

被引：37

作者：

HASSALL, CH

JOHNSON, WH

ROBERTS, NA

机构：

[1] Roche Products Limited, Welwyn Garden City, Herts

来源：

BIOORGANIC CHEMISTRY | 1979年 / 8卷 / 03期

关键词：

D O I：

10.1016/0045-2068(79)90057-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New evidence has enabled the identification of novel specific inhibitors of porcine pancreatic elastase with potential for action in vivo. The basis for optimization of activity in this series of derivatives of alanylproline, and the relationship of elastase inhibition to the binding mode, is discussed. © 1979.

引用

页码：299 / 309

页数：11

共 42 条

[21] SPECIFICITY OF PORCINE PANCREATIC ELASTASE, HUMAN LEUKOCYTE ELASTASE AND CATHEPSIN-G - INHIBITION WITH PEPTIDE CHLOROMETHYL KETONES
POWERS, JC
GUPTON, BF
HARLEY, AD
NISHINO, N
WHITLEY, RJ
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 485 (01) : 156 - 166
[22] POWERS JC, 1976, TRENDS BIOCHEM SCI, V1, P211
[23] UNUSUAL REACTIVITY OF TRIFLUOROACETYL PEPTIDE CHLOROMETHYL KETONES WITH PANCREATIC ELASTASE
RENAUD, A
DIMICOLI, JL
LESTIENNE, P
BIETH, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (03) : 1005 - 1007
[24] ATOMIC-STRUCTURE OF CRYSTALLINE PORCINE PANCREATIC ELASTASE AT 2.5 A RESOLUTION - COMPARISONS WITH STRUCTURE OF ALPHA-CHYMOTRYPSIN
SAWYER, L
SHOTTON, DM
CAMPBELL, JW
WENDELL, PL
MUIRHEAD, H
WATSON, HC
DIAMOND, R
LADNER, RC
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1978, 118 (02) : 137 - 208
[25] SAWYER L, UNPUBLISHED
[26] ON SIZE OF ACTIVE SITE IN PROTEASES .I. PAPAIN
SCHECHTER, I
BERGER, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 27 (02) : 157 - +
[27] PARA-NITROPHENYL CARBAMATES AS ACTIVE-SITE-SPECIFIC REAGENTS FOR SERINE PROTEASES
SCOFIELD, RE
WERNER, RP
WOLD, F
[J]. BIOCHEMISTRY, 1977, 16 (11) : 2492 - 2496
[28] SHOTTON D M, 1970, Nature (London), V225, P802, DOI 10.1038/225802a0
[29] SHOTTON DM, 1971, COLD SPRING HARB SYM, V36, P91
[30] RESTRICTIONS ON BINDING OF PROLINE-CONTAINING PEPTIDES TO ELASTASE
THOMPSON, RC
BLOUT, ER
[J]. BIOCHEMISTRY, 1973, 12 (01) : 51 - 57

← 1 2 3 4 5 →