EVOLUTION OF MOUSE B1 REPEATS - 7SL RNA FOLDING PATTERN CONSERVED

被引：66

作者：

LABUDA, D ^{[1
]}

SINNETT, D ^{[1
]}

RICHER, C ^{[1
]}

DERAGON, JM ^{[1
]}

STRIKER, G ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM, W-3400 GOTTINGEN, GERMANY

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1991年 / 32卷 / 05期

关键词：

B1 REPETITIVE ELEMENTS; RNA SECONDARY STRUCTURE; RETROPOSITION; CONSERVATION OF MASTER SEQUENCES;

D O I：

10.1007/BF02101280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent report mouse B1 genomic repeats were divided into six families representing different waves of fixation of B1 variants, consistent with the retroposition model of human Alu elements. These data are used to examine the distribution of nucleotide substitutions in individual genomic repeats with respect to family consensus sequences and to compare the minimal energy structures of the corresponding B1 RNAs. By an enzymatic approach the predicted structure of B1 RNAs is experimentally confirmed using as a model sequence an RNA of a young B1 family member transcribed in vitro by T7 RNA polymerase. B1 RNA preserves folding domains of the Alu fragment of 7SL RNA, its progenitor molecule. Our results reveal similarities among 7SL-like retroposons, human Alu, and rodent B1 repeats, and relate the evolutionary conservation of B1 family consensus sequences to selection at the RNA level.

引用

页码：405 / 414

页数：10

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