LIPID LOWERING THERAPY LEADS TO A REDUCTION IN SODIUM-LITHIUM COUNTERTRANSPORT ACTIVITY

被引：25

作者：

CARR, SJ

THOMAS, TH

LAKER, MF

WILKINSON, R

机构：

[1] FREEMAN RD HOSP,DEPT MED & NEPHROL,NEPHROL LABS,LEVEL 4,FREEMAN RD,NEWCASTLE TYNE NE7 7DN,TYNE & WEAR,ENGLAND

[2] ROYAL VICTORIA INFIRM,DEPT CLIN BIOCHEM,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

来源：

ATHEROSCLEROSIS | 1991年 / 87卷 / 2-3期

关键词：

SODIUM-LITHIUM COUNTERTRANSPORT; HYPERLIPIDEMIA;

D O I：

10.1016/0021-9150(91)90012-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythrocyte sodium-lithium countertransport (SLC) was measured in 17 patients with either combined hyperlipidaemia or hypercholesterolaemia before and after lipid lowering therapy. Before treatment SLC related to the serum triglyceride level and was increased in combined hyperlipidaemia. After treatment the SLC had returned to normal and the change in SLC was related to the change in serum triglyceride levels. Raised SLC is associated with essential hypertension but is not related to blood pressure. Therefore, the association of raised SLC with hyperlipidaemia and essential hypertension appears to have different underlying mechanisms.

引用

页码：103 / 108

页数：6

共 21 条

[1]

ADRANGA N, 1985, HYPERTENSION, V1, P132

[2] NA+-LI+ COUNTERTRANSPORT AND ELECTROLYTE-COMPOSITION IN ERYTHROCYTES OF PATIENTS WITH ESSENTIAL-HYPERTENSION BEFORE AND AFTER ANTIHYPERTENSIVE TREATMENT [J].