LOCALIZATION OF MITOCHONDRIAL-DNA IN NORMAL AND PATHOLOGICAL MUSCLE USING IMMUNOLOGICAL PROBES - A NEW APPROACH TO THE STUDY OF MITOCHONDRIAL MYOPATHIES

被引：19

作者：

ANDREETTA, F

TRITSCHLER, HJ

SCHON, EA

DIMAURO, S

BONILLA, E

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,ROOM 5-431,630 W 168TH ST,NEW YORK,NY 10032

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 105卷 / 01期

关键词：

ANTI-DNA; MTDNA ANTIBODY; MITOCHONDRIAL MYOPATHIES;

D O I：

10.1016/0022-510X(91)90123-O

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA(mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.

引用

页码：88 / 92

页数：5

共 19 条

[1] SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME
ANDERSON, S
BANKIER, AT
BARRELL, BG
DEBRUIJN, MHL
COULSON, AR
DROUIN, J
EPERON, IC
NIERLICH, DP
ROE, BA
SANGER, F
SCHREIER, PH
SMITH, AJH
STADEN, R
YOUNG, IG
[J]. NATURE, 1981, 290 (5806) : 457 - 465
[2] BOGENHAGEN D, 1974, J BIOL CHEM, V249, P7991
[3] IMMUNOCYTOCHEMICAL STUDY OF NEBULIN IN DUCHENNE MUSCULAR-DYSTROPHY
BONILLA, E
MIRANDA, AF
PRELLE, A
SALVIATI, G
BETTO, R
ZEVIANI, M
SCHON, EA
DIMAURO, S
ROWLAND, LP
[J]. NEUROLOGY, 1988, 38 (10) : 1600 - 1603
[4] APPLICATION OF NILE BLUE AND NILE RED, 2 FLUORESCENT-PROBES, FOR DETECTION OF LIPID DROPLETS IN HUMAN SKELETAL-MUSCLE
BONILLA, E
PRELLE, A
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1987, 35 (05) : 619 - 621
[5] MITOCHONDRIAL MYOPATHIES
DIMAURO, S
BONILLA, E
ZEVIANI, M
SERVIDEI, S
DEVIVO, DC
SCHON, EA
[J]. JOURNAL OF INHERITED METABOLIC DISEASE, 1987, 10 : 113 - 128
[6] MOLECULAR DEFECTS IN CYTOCHROME-OXIDASE IN MITOCHONDRIAL DISEASES
DIMAURO, S
ZEVIANI, M
RIZZUTO, R
LOMBES, A
NAKASE, H
BONILLA, E
MIRANDA, A
SCHON, E
[J]. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1988, 20 (03) : 353 - 364
[7] MITOCHONDRIAL MYOPATHIES
DIMAURO, S
BONILLA, E
ZEVIANI, M
NAKAGAWA, M
DEVIVO, DC
[J]. ANNALS OF NEUROLOGY, 1985, 17 (06) : 521 - 538
[8] DELETIONS OF MUSCLE MITOCHONDRIAL-DNA IN PATIENTS WITH MITOCHONDRIAL MYOPATHIES
HOLT, IJ
HARDING, AE
MORGANHUGHES, JA
[J]. NATURE, 1988, 331 (6158) : 717 - 719
[9] IMMUNOCYTOCHEMICAL STUDIES OF CYTOCHROME-OXIDASE SUBUNITS IN SKELETAL-MUSCLE OF PATIENTS WITH PARTIAL CYTOCHROME-OXIDASE DEFICIENCIES
JOHNSON, MA
KADENBACH, B
DROSTE, M
OLD, SL
TURNBULL, DM
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1988, 87 (01) : 75 - 90
[10] MYOCLONIC EPILEPSY AND RAGGED-RED FIBERS WITH CYTOCHROME-OXIDASE DEFICIENCY - NEUROPATHOLOGY, BIOCHEMISTRY, AND MOLECULAR-GENETICS
LOMBES, A
MENDELL, JR
NAKASE, H
BAROHN, RJ
BONILLA, E
ZEVIANI, M
YATES, AJ
OMERZA, J
GALES, TL
NAKAHARA, K
RIZZUTO, R
ENGEL, WK
DIMAURO, S
[J]. ANNALS OF NEUROLOGY, 1989, 26 (01) : 20 - 33

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