SYNTHESIS OF AN ADVANCED FORSKOLIN INTERMEDIATE

被引：13

作者：

BICK, S

ZIMMERMANN, S

MEUER, H

SHELDRICK, WS

WELZEL, P

机构：

[1] Fakultät für Chemie der Ruhr-Universität, D-4630 Bochum

来源：

TETRAHEDRON | 1993年 / 49卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(01)86324-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 8,13-epoxylabdane derivative rac-19 was prepared in eight steps commencing from (E,E)-farnesol (8). Key reactions are the formation of 7 from drimenal (9b) and 6, Sharpless I epoxidation (7 --> 11), epoxy alcohol oxidation (11 --> 16), reductive epoxide cleavage (16 --> 15), peracid epoxidation (15 --> 18), and the trimethylsilyl triflate-mediated conversion of 18 into 19.

引用

页码：2457 / 2468

页数：12

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