STRIKING SEQUENCE SIMILARITY OVER ALMOST 100 KILOBASES OF HUMAN AND MOUSE T-CELL RECEPTOR DNA

被引：145

作者：

KOOP, BF ^{[1
]}

HOOD, L ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT MOLEC BIOTECHNOL,SEATTLE,WA 98115

来源：

NATURE GENETICS | 1994年 / 7卷 / 01期

关键词：

D O I：

10.1038/ng0594-48

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report here the comparative DNA sequence analysis of nearly 100 kilobases of contiguous DNA in the C delta to C alpha a region of the alpha/delta T cell receptor loci (TCRAC/TCRDC) of mouse and man. This analysis - The largest genomic sequence comparison so far - provides new insights into the functions of the T cell receptor genes as well as the surrounding chromosome structure through the identification of actively conserved DNA sequences. In this comparison we have identified a very high level of organizational and noncoding sequence similarity (similar to 71%) in contrast to previous findings in the beta-globin gene cluster. This observation begins to question the notion that much of the chromosomal non-coding sequence in junk.

引用

页码：48 / 53

页数：6

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