VDJ RECOMBINATION

被引：340

作者：

ALT, FW

OLTZ, EM

YOUNG, F

GORMAN, J

TACCIOLI, G

CHEN, J

机构：

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 08期

关键词：

D O I：

10.1016/0167-5699(92)90043-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

引用

页码：306 / 314

页数：9

共 86 条

[1] HPR1, A NOVEL YEAST GENE THAT PREVENTS INTRACHROMOSOMAL EXCISION RECOMBINATION, SHOWS CARBOXY-TERMINAL HOMOLOGY TO THE SACCHAROMYCES-CEREVISIAE TOP1 GENE
AGUILERA, A
KLEIN, HL
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (04) : 1439 - 1451
[2] 2 PAIRS OF RECOMBINATION SIGNALS ARE SUFFICIENT TO CAUSE IMMUNOGLOBULIN-V-(D)-J JOINING
AKIRA, S
OKAZAKI, K
SAKANO, H
[J]. SCIENCE, 1987, 238 (4830) : 1134 - 1138
[3] THE IMMUNOBIOLOGY OF T-CELLS WITH INVARIANT GAMMA-DELTA ANTIGEN RECEPTORS
ALLISON, JP
HAVRAN, WL
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 679 - 705
[4] ORGANIZATION AND REORGANIZATION OF IMMUNOGLOBULIN GENES IN A-MULV TRANSFORMED-CELLS - REARRANGEMENT OF HEAVY BUT NOT LIGHT CHAIN GENES
ALT, F
ROSENBERG, N
LEWIS, S
THOMAS, E
BALTIMORE, D
[J]. CELL, 1981, 27 (02) : 381 - 390
[5] ACTIVITY OF MULTIPLE LIGHT CHAIN GENES IN MURINE MYELOMA CELLS PRODUCING A SINGLE, FUNCTIONAL LIGHT CHAIN
ALT, FW
ENEA, V
BOTHWELL, ALM
BALTIMORE, D
[J]. CELL, 1980, 21 (01) : 1 - 12
[6] ORDERED REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SEGMENTS
ALT, FW
YANCOPOULOS, GD
BLACKWELL, TK
WOOD, C
THOMAS, E
BOSS, M
COFFMAN, R
ROSENBERG, N
TONEGAWA, S
BALTIMORE, D
[J]. EMBO JOURNAL, 1984, 3 (06) : 1209 - 1219
[7] JOINING OF IMMUNOGLOBULIN HEAVY-CHAIN GENE SEGMENTS - IMPLICATIONS FROM A CHROMOSOME WITH EVIDENCE OF 3 D-JH FUSIONS
ALT, FW
BALTIMORE, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (13): : 4118 - 4122
[8] DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE
ALT, FW
BLACKWELL, TK
YANCOPOULOS, GD
[J]. SCIENCE, 1987, 238 (4830) : 1079 - 1087
[9] ALT FW, 1992, ANN NY ACAD SCI, V651, P277
[10] BARNES DE, 1992, CELL, V69, P594

← 1 2 3 4 5 6 7 8 9 →