H-1 MRS OF HIGH-GRADE ASTROCYTOMAS - MOBILE LIPID-ACCUMULATION IN NECROTIC TISSUE

被引:204
作者
KUESEL, AC
SUTHERLAND, GR
HALLIDAY, W
SMITH, ICP
机构
[1] NATL RES COUNCIL,INST BIODIAGNOST,WINNIPEG R3B 1Y6,MB,CANADA
[2] UNIV MANITOBA,DEPT SURG NEUROSURG,WINNIPEG R3E 0W3,MANITOBA,CANADA
[3] HLTH SCI CTR,DEPT PATHOL NEUROPATHOL,WINNIPEG R3A 1R9,MB,CANADA
关键词
D O I
10.1002/nbm.1940070308
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Sixty-four samples from six grade 4 astrocytomas were investigated ex vivo by H-1 MRS at 360 MHz and subsequently by histopathology to obtain percentages of viable and necrotic tumour and grey and white matter. MR-visible lipids were detected in 87% of tumour samples. Necrotic foci were <3 X 3 X 6 mm3. The means of the intensities/unit weight tissue of the lipid resonances at 5.33, 2.80, 1.29 and 0.89 ppm were significantly higher (p<0.05) for three sets of comparisons: samples with 85-100% vs 50-75%; with 50-75% vs 10-40% and with 10-40% vs 0-5% necrosis. For the lipid resonance at 2.04 ppm the difference in the means was significant only for samples with 50-75% compared to those with 85-100% necrosis, because for samples with <50% necrosis resonances from glutamine and possibly small amounts of glutamate, gamma-aminobutyrate and N-acetylaspartate anions contribute significantly to the spectral area at 2.0 ppm. We conclude that necrotic foci below MRI resolution yield the resonances at 1.3 and 0.9 ppm, and contribute to the intense resonance at 2.0 ppm observed in in vivo H-1 spectra of some high grade astrocytomas.
引用
收藏
页码:149 / 155
页数:7
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