DO H2 RECEPTOR ANTAGONISTS HAVE A THERAPEUTIC ROLE IN CHILDHOOD

被引:42
作者
KELLY, DA [1 ]
机构
[1] UNIV BIRMINGHAM, BIRMINGHAM, ENGLAND
关键词
HISTAMINE RECEPTOR ANTAGONISTS; CIMETIDINE; RANITIDINE; FAMOTIDINE;
D O I
10.1097/00005176-199410000-00002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Studies of the therapeutic efficacy and indications for the use of histamine (H2)-receptor antagonists (H2RAs) in children are reviewed. In adequate dosages, both ranitidine and cimetidine reduce acid output and increase intragastric pH, and H2RAs have been shown to be effective in the treatment of acid-peptic disease. Ranitidine is a more potent drug with a longer duration of action than cimetidine and thus requires less frequent administration. Dosage requirements vary according to age and clinical condition, and children require a relatively higher drug dosage (mg/kg) than adults. There is insufficient information on the long-term paediatric use of famotidine to validate its use in children, and the endocrinological side effects associated with cimetidine therapy in adults essentially preclude its long-term use in children. It is suggested that ranitidine administration is safe and effective in children with acid-peptic disease and should be considered as first-line treatment for children with severe oesophagitis or peptic ulceration and for the aspiration pneumonitis.
引用
收藏
页码:270 / 276
页数:7
相关论文
共 71 条
[1]  
AGARWAL A K, 1990, Indian Pediatrics, V27, P465
[2]   SUCRALFATE VERSUS CIMETIDINE IN THE TREATMENT OF REFLUX ESOPHAGITIS IN CHILDREN [J].
ARGUELLESMARTIN, F ;
GONZALEZFERNANDEZ, F ;
GENTLES, MG .
AMERICAN JOURNAL OF MEDICINE, 1989, 86 (6A) :73-76
[3]   BRADYCARDIA AND NEUROLOGIC DISORDERS ASSOCIATED WITH RANITIDINE IN A CHILD [J].
BALESTRAZZI, P ;
GREGORI, G ;
BERNASCONI, S ;
GIOVANNELLI, G .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1985, 139 (05) :442-442
[4]   USE OF THE INTRAESOPHAGEAL ACID PERFUSION TEST IN PROVOKING NONSPECIFIC CHEST PAIN IN CHILDREN [J].
BEREZIN, S ;
MEDOW, MS ;
GLASSMAN, M ;
NEWMAN, LJ .
JOURNAL OF PEDIATRICS, 1989, 115 (05) :709-712
[5]   PHARMACOKINETIC DETERMINATION OF RANITIDINE PHARMACODYNAMICS IN PEDIATRIC ULCER DISEASE [J].
BLUMER, JL ;
ROTHSTEIN, FC ;
KAPLAN, BS ;
YAMASHITA, TS ;
ESHELMAN, FN ;
MYERS, CM ;
REED, MD .
JOURNAL OF PEDIATRICS, 1985, 107 (02) :301-306
[6]  
BOUGLE D, 1985, GASTROEN CLIN BIOL, V9, P172
[7]  
CHIN TWF, 1982, PEDIATR PHARMACOL, V2, P285
[8]   PHARMACODYNAMICS OF FAMOTIDINE IN HUMANS [J].
CHREMOS, AN .
AMERICAN JOURNAL OF MEDICINE, 1986, 81 (4B) :3-7
[9]   EFFECTS OF RANITIDINE AND METOCLOPRAMIDE ON GASTRIC FLUID PH AND VOLUME IN CHILDREN [J].
CHRISTENSEN, S ;
FARROWGILLESPIE, A ;
LERMAN, DJ .
BRITISH JOURNAL OF ANAESTHESIA, 1990, 65 (04) :456-460
[10]   THE HEMODYNAMIC-EFFECTS OF INTRAVENOUS CIMETIDINE VERSUS RANITIDINE IN INTENSIVE-CARE UNIT PATIENTS - A DOUBLE-BLIND, PROSPECTIVE, CROSSOVER STUDY [J].
COURSIN, DB ;
FARINRUSK, C ;
SPRINGMAN, SR ;
GOELZER, SL .
ANESTHESIOLOGY, 1988, 69 (06) :975-978