CHROMOSOMAL-ABNORMALITIES DEFINE CLONAL PROLIFERATION IN CD3 - LARGE GRANULAR LYMPHOCYTE LEUKEMIA

被引：50

作者：

TANIWAKI, M

TAGAWA, S

NISHIGAKI, H

HORIIKE, S

MISAWA, S

SHIMAZAKI, C

MAEKAWA, T

FUJII, H

KITANI, T

ABE, T

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT HYG,KYOTO 602,JAPAN

[2] OSAKA UNIV,MICROBACTERIAL DIS RES INST,DEPT MED,OSAKA,JAPAN

[3] KYOTO RED CROSS HOSP,DEPT MED,KYOTO,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 33卷 / 01期

关键词：

clonal origin; LGL leukemia;

D O I：

10.1002/ajh.2830330107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Six patients with lymphoproliferative disorder of large granular lymphocytes (LDGL) were studied for chromosomal abnormalities. When the patients were divided into two groups depending on the expression of a mature antigen of T cell lineage, CD3, two with CD3 + phenotype had a stable disease, whereas three of the four patients with CD3‐ phenotype had marked hepatosplenomegaly and a highly aggressive disease. Chromosomal abnormalities were detected in four of six patients, indicating a clonal proliferation of large granular lymphocytes in individual patients. In particular, chromosomal abnormalities were found in three of the four patients with CD3‐ LDGL. all of which had a germ‐line configuration of the T cell receptor beta‐chain gene. Thus, the chromosomal abnormalities provide definitive evidence for the clonal origin of the expanded cells in the CD3‐LDGL. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：32 / 38

页数：7