THE ROLE OF DNA FRAGMENTATION IN APOPTOSIS

被引：524

作者：

BORTNER, CD ^{[1
]}

OLDENBURG, NBE ^{[1
]}

CIDLOWSKI, JA ^{[1
]}

机构：

[1] UNIV N CAROLINA,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)88932-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The formation of distinct DNA fragments of oligonucleosomal size (180-200 bp lengths) is a biochemical hallmark of apoptosis in many cells. Recent observations also suggest large DNA fragments and even single-strand cleavage events occur during cell death. These observations have raised many questions. What are the types of DNA cleavage observed during apoptosis? What are the nucleases involved? And what is the role of these nucleolytic events in apoptosis?

引用

页码：21 / 26

页数：6

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