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CLONING OF A NEW MEMBER OF THE TGF-BETA FAMILY - A PUTATIVE NEW ACTIVIN BETA(C) CHAIN

被引：174
作者：
HOTTEN, G
NEIDHARDT, H
SCHNEIDER, C
POHL, J
机构：
[1] Biopharm Gmbh, D 69115 Heidelberg
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 206卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.1086
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The complete amino acid sequence of a new member of the TGF-beta superfamily has been determined through initial degenerate PCR, subsequent cloning and nucleotide sequencing of the human cDNA. Amino acid homology comparison among members of this superfamily suggests it to be a new member of the activin/inhibin subgroup. The proposed mature part of the precursor shows 53 % amino acid identity to the activin beta(B) and 51 % identity to the activin beta(A) chain whereas beta(A) and beta(B) show an identity of 64 % to among members. (C) 1995 Academic Press, Inc.
引用
收藏
页码：608 / 613
页数：6
相关论文
共 32 条
  • [1] CONTROL OF CELL PATTERN IN THE NEURAL-TUBE - REGULATION OF CELL-DIFFERENTIATION BY DORSALIN-1, A NOVEL TGF-BETA FAMILY MEMBER
    BASLER, K
    EDLUND, T
    JESSELL, TM
    YAMADA, T
    [J]. CELL, 1993, 73 (04) : 687 - 702
  • [2] ISOLATION OF THE BOVINE AND HUMAN GENES FOR MULLERIAN INHIBITING SUBSTANCE AND EXPRESSION OF THE HUMAN-GENE IN ANIMAL-CELLS
    CATE, RL
    MATTALIANO, RJ
    HESSION, C
    TIZARD, R
    FARBER, NM
    CHEUNG, A
    NINFA, EG
    FREY, AZ
    GASH, DJ
    CHOW, EP
    FISHER, RA
    BERTONIS, JM
    TORRES, G
    WALLNER, BP
    RAMACHANDRAN, KL
    RAGIN, RC
    MANGANARO, TF
    MACLAUGHLIN, DT
    DONAHOE, PK
    [J]. CELL, 1986, 45 (05) : 685 - 698
  • [3] IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETA FAMILY MEMBERS PRESENT IN BONE-INDUCTIVE PROTEIN PURIFIED FROM BOVINE BONE
    CELESTE, AJ
    IANNAZZI, JA
    TAYLOR, RC
    HEWICK, RM
    ROSEN, V
    WANG, EA
    WOZNEY, JM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) : 9843 - 9847
  • [4] A NEW TYPE OF TRANSFORMING GROWTH FACTOR-BETA, TGF-BETA-3
    DERYNCK, R
    LINDQUIST, PB
    LEE, A
    WEN, D
    TAMM, J
    GRAYCAR, JL
    RHEE, L
    MASON, AJ
    MILLER, DA
    COFFEY, RJ
    MOSES, HL
    CHEN, EY
    [J]. EMBO JOURNAL, 1988, 7 (12) : 3737 - 3743
  • [5] INTRON-EXON STRUCTURE OF THE HUMAN TRANSFORMING GROWTH-FACTOR-BETA PRECURSOR GENE
    DERYNCK, R
    RHEE, L
    CHEN, EY
    VANTILBURG, A
    [J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (07) : 3188 - 3189
  • [6] PURIFICATION AND CHARACTERIZATION OF ERYTHROID-DIFFERENTIATION FACTOR (EDF) ISOLATED FROM HUMAN-LEUKEMIA CELL-LINE THP-1
    ETO, Y
    TSUJI, T
    TAKEZAWA, M
    TAKANO, S
    YOKOGAWA, Y
    SHIBAI, H
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 142 (03) : 1095 - 1103
  • [7] FROHMAN MA, 1990, AMPLIFICATIONS, V5, P11
  • [8] CLONING AND EXPRESSION OF RECOMBINANT HUMAN GROWTH/DIFFERENTIATION FACTOR-5
    HOTTEN, G
    NEIDHARDT, H
    JACOBOWSKY, B
    POHL, J
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (02) : 646 - 652
  • [9] COMPLEMENTARY DEOXYRIBONUCLEIC-ACID CLONING OF A MESSENGER RIBONUCLEIC-ACID ENCODING TRANSFORMING GROWTH FACTOR-BETA-4 FROM CHICKEN-EMBRYO CHONDROCYTES
    JAKOWLEW, SB
    DILLARD, PJ
    SPORN, MB
    ROBERTS, AB
    [J]. MOLECULAR ENDOCRINOLOGY, 1988, 2 (12) : 1186 - 1195
  • [10] THE TGF-BETA SUPERFAMILY - NEW MEMBERS, NEW RECEPTORS, AND NEW GENETIC TESTS OF FUNCTION IN DIFFERENT ORGANISMS
    KINGSLEY, DM
    [J]. GENES & DEVELOPMENT, 1994, 8 (02) : 133 - 146
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