DEVELOPMENTAL REGULATION OF NUCLEAR GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引:82
作者
CLAYTON, C
机构
[1] Zentrum für Molekulare Biologie, D-6900 Heidelberg
来源
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY | 1992年 / 43卷
关键词
D O I
10.1016/S0079-6603(08)61043-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The kinetoplastids branched very early in eukaryotic evolution and exhibit several remarkable aspects of biochemistry and molecular biology. In addition to increasing the appreciation of the range of options available in eukaryotic biochemistry, each discovery of a difference between trypanosomes and their hosts gives hope for the development of new types of drugs. African trypanosomes grow in two rather different environments: the mammalian extracellular fluids and the alimentary system of the tsetse fly. Survival in the mammal depends on an ability to evade the host immune response; the different conditions in the fly necessitate numerous metabolic adapations. This chapter summarizes the available knowledge on the development regulation of nuclear gene expression in T. brucei brucei, a close relative of T. b. rhodesiense, which is a favorite model organism because it infects cattle and other animals but not humans. The chapter particularly emphasizes the transcription of the genes encoding the major surface proteins. Some important examples from other kinetoplastids, particularly Leishmania species, are also mentioned in the chapter. © 1992, ACADEMIC PRESS, INC.
引用
收藏
页码:37 / 66
页数:30
相关论文
共 138 条
  • [1] TRANSSPLICING OF NUCLEAR PRE-MESSENGER-RNAS
    AGABIAN, N
    [J]. CELL, 1990, 61 (07) : 1157 - 1160
  • [2] DIFFERENTIAL EXPRESSION OF A FAMILY OF PUTATIVE ADENYLATE GUANYLATE-CYCLASE GENES IN TRYPANOSOMA-BRUCEI
    ALEXANDRE, S
    PAINDAVOINE, P
    TEBABI, P
    PAYS, A
    HALLEUX, S
    STEINERT, M
    PAYS, E
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 43 (02) : 279 - 288
  • [3] PUTATIVE GENES OF A VARIANT-SPECIFIC ANTIGEN GENE-TRANSCRIPTION UNIT IN TRYPANOSOMA-BRUCEI
    ALEXANDRE, S
    GUYAUX, M
    MURPHY, NB
    COQUELET, H
    PAYS, A
    STEINERT, M
    PAYS, E
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (06) : 2367 - 2378
  • [4] KEY FEATURES OF HEAT-SHOCK REGULATORY ELEMENTS
    AMIN, J
    ANANTHAN, J
    VOELLMY, R
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) : 3761 - 3769
  • [5] ATWATER JA, 1990, ANNU REV GENET, V24, P519
  • [6] THE INVITRO DIFFERENTIATION OF PLEOMORPHIC TRYPANOSOMA-BRUCEI FROM BLOOD-STREAM INTO PROCYCLIC FORM REQUIRES NEITHER INTERMEDIARY NOR SHORT-STUMPY STAGE
    BASS, KE
    WANG, CC
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 44 (02) : 261 - 270
  • [7] EXPRESSION OF A BACTERIAL GENE IN A TRYPANOSOMATID PROTOZOAN
    BELLOFATTO, V
    CROSS, GAM
    [J]. SCIENCE, 1989, 244 (4909) : 1167 - 1169
  • [8] STRUCTURE AND TRANSCRIPTION OF THE ACTIN GENE OF TRYPANOSOMA-BRUCEI
    BENAMAR, MF
    PAYS, A
    TEBABI, P
    DERO, B
    SEEBECK, T
    STEINERT, M
    PAYS, E
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) : 2166 - 2176
  • [9] BENAMAR MF, 1991, NUCLEIC ACIDS RES, V19, P5857, DOI 10.1093/nar/19.21.5857
  • [10] BERBEROF M, 1991, MOL CELL BIOL, V11, P1473, DOI 10.1128/MCB.11.3.1473