SEASONAL DIFFERENCES AND EFFECT OF INSULIN ON PYRUVATE UPTAKE OXIDATION AND SYNTHESIS TO GLYCOGEN BY FROG SKELETAL MUSCLE

1. 1. In frog sartorius muscle, insulin stimulated the uptake of pyruvate, the synthesis of pyruvate to glycogen, and in summer, but not in winter, the oxidation of pyruvate. 2. 2. Insulin shifted the utilization of pyruvate away from pathways not studied in this investigation. In summer muscles, the major shift was toward oxidation, while in winter muscles, the major shift was toward glycogen synthesis. © 1969.