NEUROPATHY, AMYLOIDOSIS, AND MONOCLONAL GAMMOPATHY

被引:31
作者
FITTING, JW [1 ]
BISCHOFF, A [1 ]
REGLI, F [1 ]
CROUSAZ, GD [1 ]
机构
[1] UNIV BERN,DEPT NEUROL,CH-3000 BERN,SWITZERLAND
关键词
D O I
10.1136/jnnp.42.3.193
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Three cases of neuropathy with monoclonal gammopathy and amyloid deposits in peripheral nerves are described. They appeared to present a benign gammopathy because of the duration of the neuropathy in the absence of any clinical or biological sign of myeloma or macroglobulinaemia. The pathological abnormality found in the sural nerves of the three patients was characterised by a marked loss of myelinated and unmyelinated nerve fibres because of active axonal degeneration with Wallerian degeneration. The most striking feature in all three cases was the finding of deposits identified as an accumulation of microfibrils.
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页码:193 / 202
页数:10
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共 32 条
[11]  
CONTAMIN F, 1976, REV NEUROL, V132, P741
[12]   NEUROPATHY DUE TO AMYLOID IN MYELOMATOSIS [J].
DAVIESJONES, GA ;
ESIRI, MM .
BMJ-BRITISH MEDICAL JOURNAL, 1971, 2 (5759) :444-+
[13]   MYELOMA NEUROPATHY - SUCCESSFUL TREATMENT OF 2 PATIENTS AND REVIEW OF CASES [J].
DAVIS, LE ;
DRACHMAN, DB .
ARCHIVES OF NEUROLOGY, 1972, 27 (06) :507-&
[14]   Myeloma and its neural complications [J].
Davison, C ;
Balser, BH .
ARCHIVES OF SURGERY, 1937, 35 (05) :913-936
[15]   PERIPHERAL NEUROPATHY AND MYELOMA [J].
DAYAN, AD ;
URICH, H ;
GARDNERT.C .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1971, 14 (01) :21-&
[16]  
Engel W K, 1976, Adv Neurol, V15, P119
[17]  
FORSSMAN O, 1973, SCAND J HAEMATOL, V11, P332
[18]  
GLENNER G G, 1975, Annals of Clinical and Laboratory Science, V5, P257
[19]  
HESSELVIK M, 1969, ACTA NEUROL SCAND, V45, P95
[20]   BENIGN MONOCLONAL GAMMOPATHY - A POTENTIALLY MALIGNANT CONDITION [J].
KYLE, RA ;
BAYRD, ED .
AMERICAN JOURNAL OF MEDICINE, 1966, 40 (03) :426-&