INVITRO ACTIVITY OF THE ENANTIOMERS OF MEFLOQUINE, HALOFANTRINE AND ENPIROLINE AGAINST PLASMODIUM-FALCIPARUM

被引：58

作者：

BASCO, LK

GILLOTIN, C

GIMENEZ, F

FARINOTTI, R

LEBRAS, J

机构：

[1] HOP LA PITIE SALPETRIERE,DEPT PHARM & PHARMACOKINET,F-75013 PARIS,FRANCE

[2] HOP BICHAT CLAUDE BERNARD,DEPT CLIN PHARM,F-75018 PARIS,FRANCE

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 05期

关键词：

PLASMODIUM-FALCIPARUM; MALARIA; MEFLOQUINE; HALOFANTRINE; ENPIROLINE; ENANTIOMERS;

D O I：

10.1111/j.1365-2125.1992.tb04081.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The in vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline was compared against chloroquine-resistant and -susceptible strains of Plasmodium falciparum using a semi-micro drug susceptibility test. For each strain, the corresponding enantiomers exhibited similar activities. The enantiomers of halofantrine were the most active against both susceptible and resistant strains, followed by the enantiomers of mefloquine and enpiroline.

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页码：517 / 520

页数：4

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