NEW ORGANOGERMYLATED COMPOUNDS N-SUBSTITUTED BY NAPHTHYLMETHYLIMIDAZOLINE HYDROCHLORIDE, AND IMIDAZOLINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY

被引：6

作者：

RIMA, G

SATGE, J

SENTENACROUMANOU, H

FATOME, M

LION, C

LAVAL, JD

机构：

[1] UNIV TOULOUSE 3,CHIM ORGANOMINERAUX LAB,URA 477,118 ROUTE NARBONNE,F-31062 TOULOUSE,FRANCE

[2] SERV SANTE ARMEES,CTR RECH,DIV RADIOBIOL,F-38702 LA TRONCHE,FRANCE

[3] UNIV PARIS 07,INST TOPOL & DYNAM SYST,CNRS,F-75221 PARIS 05,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 10期

关键词：

GERMYLATED DERIVATIVES; NAPHTHYLMETHYLIMIDAZOLINE; IMIDAZOLINE; RADIOPROTECTIVE ACTIVITY; TOXICITY;

D O I：

10.1016/0223-5234(93)90111-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This work concerns the synthesis and pharmacological study (toxicity, radioprotective activity) of the N-substituted organogermylated compounds by naphthylmethylimidazoline hydrochloride and imidazoline. These new organometallic derivatives have quite low toxicity and sometimes higher radioprotective activity (compared with hydrochlorides of naphthylmethylimidazoline and imidazoline).

引用

页码：761 / 767

页数：7