FIBROBLAST INTERFERON TREATMENT OF A PATIENT WITH CHRONIC ACTIVE HEPATITIS - INCREASED NUMBER OF CIRCULATING LYMPHOCYTES-T AND ELIMINATION OF ROSETTE-INHIBITORY FACTOR

被引：29

作者：

DOLEN, JG

CARTER, WA

HOROSZEWICZ, JS

VLADUTIU, AO

LEIBOWITZ, AI

NOLAN, JP

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT MED VIRAL ONCOL,BUFFALO,NY 14263

[2] SUNY BUFFALO,DEPT MED,BUFFALO,NY 14214

[3] SUNY BUFFALO,DEPT PATHOL,BUFFALO,NY 14214

来源：

AMERICAN JOURNAL OF MEDICINE | 1979年 / 67卷 / 01期

关键词：

D O I：

10.1016/0002-9343(79)90088-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 23 year old woman with chronic active hepatitis documented by liver biopsy demonstrated persistent hepatitis B surface antigen, hepatitis B virus specific DNA polymerase hepatitis B core antigen (HBcAg), for approximately one year. The number of circulating T lymphocytes that resetted with sheep erythrocytes was decreased, and a rosette-inhibitory factor was present in her peripheral blood. Interferon treatment (1 × 106 U/day intramuscularly for 82 days) resulted in a decrease of HBsAg and disappearance of HBcAg, (HBeAg) and specific DNA polymerase. In addition, the number of T lymphocytes increased to normal, and the rosette-inhibitory factor disappeared from the circulation. These findings suggest that the effect of interferon in chronic active hepatitis is mediated in part through its action on the immune system. © 1979.

引用

页码：127 / 131

页数：5