INTERACTIONS OF OXIDANT STRESS AND VASCULAR REACTIVITY

被引：43

作者：

GURTNER, GH

BURKEWOLIN, T

机构：

[1] NEW YORK MED COLL, DEPT MED, VALHALLA, NY 10595 USA

[2] NEW YORK MED COLL, DEPT PHYSIOL, VALHALLA, NY 10595 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 260卷 / 04期

关键词：

PULMONARY CIRCULATION; ARACHIDONIC ACID; CYCLOOXYGENASE; GUANYLATE CYCLASE; HYDROGEN PEROXIDE; ORGANIC PEROXIDE;

D O I：

10.1152/ajplung.1991.260.4.L207

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Oxidants have complex effects on pulmonary vascular reactivity. They can stimulate production of vasoconstrictor arachidonate mediators and can also cause vasodilation through activation of guanylate cyclase. Oxidants can also inactivate vasomotor phenomenon by interfering with mechanisms of signal transduction or smooth muscle contraction. The final physiological response depends on the balance of these complex actions.

引用

收藏

页码：L207 / L211

页数：5

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