SYNTHESIS AND BIOLOGICAL-ACTIVITY OF C-6 MODIFIED DERIVATIVES OF THE GLUCOSIDASE INHIBITOR 1-DEOXYNOJIRIMYCIN

被引：19

作者：

BERGER, A

DAX, K

GRADNIG, G

GRASSBERGER, V

STUTZ, AE

UNGERANK, M

LEGLER, G

BAUSE, E

机构：

[1] GRAZ TECH UNIV,INST ORGAN CHEM,STREMAYRGASSE 16,A-8010 GRAZ,AUSTRIA

[2] UNIV COLOGNE,INST BIOCHEM,W-5000 COLOGNE,GERMANY

[3] UNIV BONN,INST PHYSIOL CHEM,W-5300 BONN,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80648-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel 1-deoxynojirimycin derivative, (6S)-6-C-ethyl-1-deoxynojirimycin, was synthesized and tested on a set of alpha- and beta-glucosidases. Its enzyme inhibitory activity against alpha-glucosidases from yeast and rice was superior to those of 1,6-dideoxy-6-fluoronojirimycin, 1-deoxynojirimycin and its bicyclic analogue, castanospermine.

引用

页码：27 / 32

页数：6

共 33 条

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