VALPROATE TREATMENT OF MANIA

被引：24

作者：

EMRICH, HM

WOLF, R

机构：

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1992年 / 16卷 / 05期

关键词：

ANTICONVULSANTS; GABA; MANIA; VALPROATE;

D O I：

10.1016/0278-5846(92)90025-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Acute as well as prophylactic effects of the anticonvulsant valproate are described in patients with mania and bipolar affective psychoses. 2. In a long-term evaluation of valproate prophylaxis ranging up to 14 years, an average improvement of the phase chart of 12 patients was observed by a factor of 12. 3. The mode of action of this effect appears to be related to the GABAergic properties of the compound.

引用

页码：691 / 701

页数：11

共 25 条

[1]

Bernasconi R., 1984, ANTICONVULSANTS AFFE, P14

[2]

Bernasconi R., 1982, BASIC MECHANISMS ACT, P183

[3]

Brennan MJW, 1984, ANTICONVULSANTS AFFE, P56

[4] ACTION OF PROPRANOLOL IN MANIA - COMPARISON OF EFFECTS OF THE D-STEREOISOMER AND THE L-STEREOISOMER [J].