DEFECTIVE P ELEMENT INSERTIONS AFFECT THE EXPRESSION OF SN-GLYCEROL-3-PHOSPHATE DEHYDROGENASE ALLELES IN NATURAL-POPULATIONS OF DROSOPHILA-MELANOGASTER

被引:11
作者
REED, DS [1 ]
GIBSON, JB [1 ]
机构
[1] AUSTRALIAN NATL UNIV, RES SCH BIOL SCI, MOLEC & POPULAT GENET GRP, POB 475, CANBERRA, ACT 2601, AUSTRALIA
关键词
D O I
10.1098/rspb.1993.0006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A distinctive and geographically widespread category of low-activity variant at the Gpdh locus in Drosophila melanogaster is shown to have defective P elements inserted between the TATA box and the transcription start site. In four examples the insertion was a single 1.15 kilobase (kb) KP element, whereas in another variant there were two KP elements in tandem. A sixth example contained a 0.61 kb defective P element. The target site for all of the insertions is GTGCAAAC. There was no sequence variation either between the insertions or in comparison with two other KP elements previously described from natural populations. The insertions cause a reduction in GPDH mRNA, and are the most likely cause of the low GPDH activity.
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页码:39 / 45
页数:7
相关论文
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