PARTIAL DESTRUCTION OF BORRELIA-BURGDORFERI WITHIN TICKS THAT ENGORGED ON OSPE-IMMUNIZED OR OSPF-IMMUNIZED MICE

被引:74
作者
NGUYEN, TPK
LAM, TT
BARTHOLD, SW
TELFORD, SR
FLAVELL, RA
FIKRIG, E
机构
[1] YALE UNIV,SCH MED,DEPT INTERNAL MED,RHEUMATOL SECT,NEW HAVEN,CT 06520
[2] YALE UNIV,SCH MED,IMMUNOBIOL SECT,NEW HAVEN,CT 06520
[3] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06520
[4] YALE UNIV,SCH MED,COMPARAT MED SECT,NEW HAVEN,CT 06520
[5] HARVARD UNIV,SCH PUBL HLTH,DEPT TROP PUBL HLTH,BOSTON,MA 02115
关键词
D O I
10.1128/IAI.62.5.2079-2084.1994
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We determined whether Borrelia burgdorferi outer surface proteins (Osps) E and F could elicit immune responses useful for a Lyme disease vaccine. Thirty days after challenge with B. burgdorferi, mice produced antibodies to OspE but not OspF, whereas antibodies to OspF were present in sera of mice obtained 90 days after infection. Examination of sera from patients with Lyme disease revealed antibodies to OspF in a small number (14%) of early-stage disease patients but in a majority (58%) of patients with late-stage disease, while antibodies to OspE mere rarely detected in patients. Mice immunized with recombinant OspE or OspF produced high titers of antibodies to OspE or OspF, respectively. OspF-immunized mice were partially protected from both intradermal syringe challenge and tick-mediated transmission of B. burgdorferi while vaccination with OspE did not confer immunity. B. burgdorferi organisms were, however, substantially destroyed within ticks that engorged on either OspE- (75% reduction in the number of spirochetes within the ticks, compared with controls) or OspF (90% reduction in the number of spirochetes within the ticks)-immunized mice.
引用
收藏
页码:2079 / 2084
页数:6
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