MAGNETIC-RESONANCE-IMAGING EVALUATION OF THE EFFECTS OF AGING ON GRAY-WHITE RATIO IN THE HUMAN BRAIN

被引：23

作者：

HARRIS, GJ ^{[1
]}

SCHLAEPFER, TE ^{[1
]}

PENG, LW ^{[1
]}

LEE, S ^{[1
]}

FEDERMAN, EB ^{[1
]}

PEARLSON, GD ^{[1
]}

机构：

[1] JOHNS HOPKINS MED INST,DEPT PSYCHIAT,DIV PSYCHIAT NEUROIMAGING,BALTIMORE,MD 21205

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1994年 / 20卷 / 03期

关键词：

MAGNETIC RESONANCE IMAGING; AGING; BRAIN; GRAY MATTER; WHITE MATTER;

D O I：

10.1111/j.1365-2990.1994.tb00971.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A previous neuropathological report noted a non-linear pattern of change in cerebral grey-white matter ratio during ageing. In that report, grey-white ratio decreased from age 20 to age 50, then increased in elderly subjects. The objective of the current study was to attempt to replicate this pattern of age-related change in the grey-white ratio in living human subjects using quantitative magnetic resonance imaging segmentation analysis. We measured the grey-white ratio in 78 subjects between the ages of 19 and 77 years, using a computer segmentation algorithm with magnetic resonance images. In agreement with the previous neuropathological report, the current in vivo magnetic resonance study found that the grey-white ratio declined from age 20 to age 50, then increased in elderly subjects.

引用

页码：290 / 293

页数：4

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