SYNTHESIS OF DOUBLY AND MULTIPLY ISOTOPICALLY LABELED RETINALS

被引:34
作者
GROESBEEK, M [1 ]
LUGTENBURG, J [1 ]
机构
[1] LEIDEN UNIV, GORLAEUS LABS, DEPT CHEM, POB 9502, 2300 RA LEIDEN, NETHERLANDS
关键词
D O I
10.1111/j.1751-1097.1992.tb09711.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this paper a consecutive synthetic scheme is described that allows the synthesis of multiply C-13 labeled retinals with labels in the conjugated chain. This scheme can be extended to incorporation of H-2 labels in the conjugated chain. Also carotenoids can be multiply C-13 labeled with this strategy. The same approach has been used to label amino acids.
引用
收藏
页码:903 / 908
页数:6
相关论文
共 33 条
  • [1] BACTERIORHODOPSINS M412 INTERMEDIATE CONTAINS A 13-CIS, 14-S-TRANS, 15-ANTI-RETINAL SCHIFF-BASE CHROMOPHORE
    AMES, JB
    FODOR, SPA
    GEBHARD, R
    RAAP, J
    VANDENBERG, EMM
    LUGTENBURG, J
    MATHIES, RA
    [J]. BIOCHEMISTRY, 1989, 28 (09) : 3681 - 3687
  • [2] [Anonymous], 1982, EUR J BIOCHEM, V129, P1
  • [3] CAPPON JJ, 1991, RECL TRAV CHIM PAY B, V110, P158
  • [4] DETERMINATION OF MEMBRANE-PROTEIN STRUCTURE BY ROTATIONAL RESONANCE NMR - BACTERIORHODOPSIN
    CREUZET, F
    MCDERMOTT, A
    GEBHARD, R
    VANDERHOEF, K
    SPIJKERASSINK, MB
    HERZFELD, J
    LUGTENBURG, J
    LEVITT, MH
    GRIFFIN, RG
    [J]. SCIENCE, 1991, 251 (4995) : 783 - 786
  • [5] BACTERIORHODOPSINS L550 INTERMEDIATE CONTAINS A C14-C15 S-TRANS-RETINAL CHROMOPHORE
    FODOR, SPA
    POLLARD, WT
    GEBHARD, R
    VANDENBERG, EMM
    LUGTENBURG, J
    MATHIES, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) : 2156 - 2160
  • [6] CHROMOPHORE STRUCTURE IN BACTERIORHODOPSINS-N INTERMEDIATE - IMPLICATIONS FOR THE PROTON-PUMPING MECHANISM
    FODOR, SPA
    AMES, JB
    GEBHARD, R
    VANDENBERG, EMM
    STOECKENIUS, W
    LUGTENBURG, J
    MATHIES, RA
    [J]. BIOCHEMISTRY, 1988, 27 (18) : 7097 - 7101
  • [7] STRUCTURE OF THE RETINAL CHROMOPHORE IN THE HRL INTERMEDIATE OF HALORHODOPSIN FROM RESONANCE RAMAN-SPECTROSCOPY
    FODOR, SPA
    BOGOMOLNI, RA
    MATHIES, RA
    [J]. BIOCHEMISTRY, 1987, 26 (21) : 6775 - 6778
  • [8] FODOR SPA, 1989, J BIOL CHEM, V264, P18280
  • [9] GEBHARD R, 1990, RECL TRAV CHIM PAY B, V109, P378
  • [10] GEBHARD R, 1991, RECL TRAV CHIM PAY B, V110, P332