UNEXPECTED EFFECTS OF LEWIS-ACIDS IN THE SYNTHESIS OF OPTICALLY PURE 2'-DEOXY-3'-OXACYTIDINE NUCLEOSIDE ANALOGS

被引：10

作者：

JIN, HL

TSE, HLA

EVANS, CA

MANSOUR, TS

BEELS, CM

RAVENSCROFT, P

HUMBER, DC

JONES, MF

PAYNE, JJ

RAMSAY, MVJ

机构：

[1] BIOCHEM PHARMA INC,531 PRAIRIES BLVD,LAVAL H7V 1B7,PQ,CANADA

[2] GLAXO GRP RES LTD,DEPT CHEM DEV,WARE SG1 2OD,HERTS,ENGLAND

[3] GLAXO GRP RES LTD,MED CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)82340-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

TiCl4 and SnCl4 promote the formation of dioxolane nucleosides with racemization in the coupling of enantiomerically pure 2'-deoxy-3'oxaribosides with silylated N-acetylcytosine. The use of TMSOTf, TMSI or TiCl2(Oi-Pr)2 furnishes enantiomerically pure cytosine dioxolane nucleosides in low diastereoselectivity.

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页码：211 / 214

页数：4

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