PRECISE MAPPING OF T(12-14) LEIOMYOMA BREAKPOINT ON CHROMOSOME-14 BETWEEN D14S298 AND D14S540

被引：11

作者：

DONEY, MK

GERKEN, SC

LYNCH, R

BHUGRA, B

HUG, K

WHITE, R

WEISSENBACH, J

MENON, AG

机构：

[1] UNIV CINCINNATI,COLL MED,DEPT MOLEC GENET BIOCHEM & MICROBIOL,CINCINNATI,OH 45267

[2] UNIV UTAH,DEPT HUMAN GENET,SALT LAKE CITY,UT 84112

[3] GENETHON,CNRS,URA 1922,F-91000 EVRY,FRANCE

来源：

CANCER LETTERS | 1995年 / 96卷 / 02期

关键词：

LEIOMYOMA; TUMOR; SMOOTH MUSCLE; CHROMOSOMAL TRANSLOCATION;

D O I：

10.1016/0304-3835(95)03938-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uterine leiomyoma is a common tumor of smooth muscle cell origin often characterized by the presence of a balanced t(12;14)(q13-15;q24.1) chromosomal translocation. This breakpoint on chromosome 14 had previously been placed between the markers SPTB and D14S77, a region estimated to span 7 cM. In this study we have used a meiotic breakpoint mapping panel to construct a high resolution genetic map of this interval. Markers that mapped within this interval were used to analyze DNA from a somatic cell hybrid containing the t(12;14) translocated chromosome. The results of this analysis localize the t(12;14) breakpoint on chromosome 14 between D14S298 and D14S540, between which no meiotic recombination was detected. This sets the stage for identifying the gene(s) disrupted by the chromosomal translocation by defining the markers that flank the translocation breakpoint.

引用

页码：245 / 252

页数：8

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