COENZYME-Q HOMOLOGS IN PARASITIC PROTOZOA AS TARGETS FOR CHEMOTHERAPEUTIC ATTACK

被引：50

作者：

ELLIS, JE

机构：

[1] Jayne Ellis is at the Department of Biological Sciences, University of Cincinnati, Cincinnati

来源：

PARASITOLOGY TODAY | 1994年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0169-4758(94)90079-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The central role of coenzyme Q (ubiquinone) in cellular energy metabolism is well established. Recent work has implicated this molecule in a wide range of other cellular functions, including roles in growth control, plasma membrane oxidase and as a cellular antioxidant. In this review, Jayne Ellis presents an overview of the current knowledge of this important cellular component in species of parasitic protozoa, discusses current therapies using its analogs and proposes its potential roles in these organisms.

引用

页码：296 / 301

页数：6

共 53 条

[1] CHLOROQUINE-SENSITIVE TRANSPLASMALEMMA ELECTRON-TRANSPORT IN TETRAHYMENA-PYRIFORMIS - A HYPOTHESIS FOR CONTROL OF PARASITE PROTOZOA THROUGH TRANSMEMBRANE REDOX [J].