METHOTREXATE AND TRIMETHOPRIM SULFAMETHOXAZOLE - A POTENTIALLY HAZARDOUS COMBINATION

被引：57

作者：

GROENENDAL, H ^{[1
]}

RAMPEN, FHJ ^{[1
]}

机构：

[1] ST ANNA HOSP,DEPT DERMATOL,J ZWIJSENLAAN 12,5342 BT OSS,NETHERLANDS

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1990年 / 15卷 / 05期

关键词：

D O I：

10.1111/j.1365-2230.1990.tb02113.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 74‐year‐old woman had been treated with methotrex‐ate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non‐healing leg ulcers. After being treated with trimethoprim‐sulphamethoxazole for a urinary‐tract infection, she developed severe pancytopenia, followed by pneumonia and septic‐shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：358 / 360

页数：3

共 13 条

[1] PANCYTOPENIA FOLLOWING LOW-DOSE METHOTREXATE THERAPY [J].

ABEL, EA ;

FARBER, EM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 259 (24) :3612-3612

[2] METHOTREXATE PNEUMONITIS AFTER LOW-DOSE THERAPY FOR RHEUMATOID-ARTHRITIS [J].

ENGELBRECHT, JA ;

CALHOON, SL ;

SCHERRER, JJ .

ARTHRITIS AND RHEUMATISM, 1983, 26 (10) :1275-1278

[3]

EVANS WE, 1985, J RHEUMATOL, V12, P15

[4] PANCYTOPENIA ASSOCIATED WITH LOW-DOSE PULSE METHOTREXATE IN THE TREATMENT OF RHEUMATOID-ARTHRITIS [J].

MACKINNON, SK ;

STARKEBAUM, G ;

WILLKENS, RF .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1985, 15 (02) :119-126

[5] MEGALOBLASTIC PANCYTOPENIA IN A PATIENT RECEIVING CONCURRENT METHOTREXATE AND TRIMETHOPRIM-SULFAMETHOXAZOLE TREATMENT [J].

MARICIC, M ;

DAVIS, M ;

GALL, EP .

ARTHRITIS AND RHEUMATISM, 1986, 29 (01) :133-135

[6] METHOTREXATE IN PSORIASIS - REVISED GUIDELINES [J].

ROENIGK, HH ;

AUERBACH, R ;

MAIBACH, HI ;

WEINSTEIN, GD .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 19 (01) :145-156

[7]

SHUPACK JL, 1988, JAMA-J AM MED ASSOC, V259, P3594

[8] PNEUMONITIS COMPLICATING LOW-DOSE METHOTREXATE THERAPY IN RHEUMATOID-ARTHRITIS [J].

STCLAIR, EW ;

RICE, JR ;

SNYDERMAN, R .

ARCHIVES OF INTERNAL MEDICINE, 1985, 145 (11) :2035-2038

[9]

THOMAS DR, 1987, J AM ACAD DERMATOL, V17, P1055

[10]

THOMAS MH, 1986, J RHEUMATOL, V13, P440

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