METHOTREXATE AND TRIMETHOPRIM SULFAMETHOXAZOLE - A POTENTIALLY HAZARDOUS COMBINATION

被引：57

作者：

GROENENDAL, H ^{[1
]}

RAMPEN, FHJ ^{[1
]}

机构：

[1] ST ANNA HOSP,DEPT DERMATOL,J ZWIJSENLAAN 12,5342 BT OSS,NETHERLANDS

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1990年 / 15卷 / 05期

关键词：

D O I：

10.1111/j.1365-2230.1990.tb02113.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 74‐year‐old woman had been treated with methotrex‐ate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non‐healing leg ulcers. After being treated with trimethoprim‐sulphamethoxazole for a urinary‐tract infection, she developed severe pancytopenia, followed by pneumonia and septic‐shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：358 / 360

页数：3