GENOME OF AVIAN MYELOCYTOMATOSIS VIRUS-MC29 - ANALYSIS BY HETERODUPLEX MAPPING

被引：57

作者：

HU, SSF

LAI, MMC

VOGT, PK

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 03期

关键词：

D O I：

10.1073/pnas.76.3.1265

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The virion RNA of avian myelocytoma virus MC29 was hybridized to full genome length DNA of the Prague strain of Rous sarcoma virus and analyzed by heteroduplex mapping in the electron microscope. The results show that MC29 specific sequences for which there are no homologous counterparts in the Rous sarcoma virus genome make up a contiguous stretch of RNA about 1.8 kilobases long. These sequences are located approximately in the middle of the genome, replacing the 3' half of the gag gene, the entire pol gene, and the 5' portion of the env gene, which are absent from MC29. This MC29 specific genetic substitution may contain information for the leukemogenic transformation of the host cell.

引用

页码：1265 / 1268

页数：4

共 26 条

[21] HIGH-FREQUENCY OF ABERRANT EXPRESSION OF MOLONEY MURINE LEUKEMIA-VIRUS IN CLONAL INFECTIONS [J].