EFFECTS OF SEDATIVES ON GABA-MEDIATED CHLORIDE FLUX INTO CEREBRAL CORTICAL MICROSACS PREPARED FROM EMOTIONAL AND NONEMOTIONAL MICE

被引:9
作者
MIHIC, SJ
VANBERCKEL, BNM
ODOWD, BF
NGUYEN, T
WU, PH
机构
[1] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A8,ONTARIO,CANADA
[2] ADDICT RES FDN ONTARIO,TORONTO,ONTARIO,CANADA
[3] UNIV UTRECHT,FAC MED,RUDOLF MAGNUS INST PHARMACOL,UTRECHT,NETHERLANDS
关键词
EMOTIONALITY; GABA (GAMMA-AMINOBUTYRIC ACID); DIAZEPAM; PENTOBARBITAL; CL-; FLUX; (MOUSE);
D O I
10.1016/0014-2999(92)90180-C
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Some strains of rats and mice express increased momentary fear or emotionality when exposed to a novel environment. Previous studies have found significantly fewer diazepam binding sites in the brains of Balb/cJ mice compared to C57BL and AKR/J mice and this has been suggested to contribute to the increased emotionality of the 'nervous' Balb strain. The influx of Cl-36 into cerebral cortical microsacs was used to functionally assess the effects of GABA, diazepam and pentobarbital in the Balb mice compared to nonemotional animals (C57 and ICR mice). Slight differences in the ability of GABA to increase chloride influx were found among the three strains. Pentobarbital potentiation of GABA-mediated chloride flux was slightly higher in the ICR mice compared to Balb and C57. Diazepam potentiation of the effects of GABA, however, was significantly decreased in the Balb mice, strengthening the hypothesis that the benzodiazepine receptor is involved in mediating animal emotionality.
引用
收藏
页码:283 / 286
页数:4
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