SIGNAL-TRANSDUCTION EVENTS LEADING TO T-CELL LYMPHOKINE GENE-EXPRESSION

被引:153
作者
FRASER, JD [1 ]
STRAUS, D [1 ]
WEISS, A [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143
来源
IMMUNOLOGY TODAY | 1993年 / 14卷 / 07期
关键词
D O I
10.1016/0167-5699(93)90236-E
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The expression of T-cell derived lymphokines is regulated by signal transduction events initiated by the T-cell antigen receptor and other T-cell surface molecules. Substantial progress has been made in characterizing the signal transduction events initiated at the Plasma membrane of the T cell and their targets which control lymphokine gene expression in the nucleus. This review will summarize recent progress in this area of investigation.
引用
收藏
页码:357 / 362
页数:6
相关论文
共 69 条
  • [11] THE REGULATION AND FUNCTION OF P21RAS IN T-CELLS
    DOWNWARD, J
    GRAVES, J
    CANTRELL, D
    [J]. IMMUNOLOGY TODAY, 1992, 13 (03): : 89 - 92
  • [12] VCP, THE MAMMALIAN HOMOLOG OF CDC48, IS TYROSINE PHOSPHORYLATED IN RESPONSE TO T-CELL ANTIGEN RECEPTOR ACTIVATION
    EGERTON, M
    ASHE, OR
    CHEN, D
    DRUKER, BJ
    BURGESS, WH
    SAMELSON, LE
    [J]. EMBO JOURNAL, 1992, 11 (10) : 3533 - 3540
  • [13] NUCLEAR-ASSOCIATION OF A T-CELL TRANSCRIPTION FACTOR BLOCKED BY FK-506 AND CYCLOSPORINE-A
    FLANAGAN, WM
    CORTHESY, B
    BRAM, RJ
    CRABTREE, GR
    [J]. NATURE, 1991, 352 (6338) : 803 - 807
  • [14] REGULATION OF T-CELL LYMPHOKINE GENE-TRANSCRIPTION BY THE ACCESSORY MOLECULE CD28
    FRASER, JD
    WEISS, A
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (10) : 4357 - 4363
  • [15] CD28 AND T-CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION COORDINATELY REGULATE INTERLEUKIN-2 GENE-EXPRESSION IN RESPONSE TO SUPERANTIGEN STIMULATION
    FRASER, JD
    NEWTON, ME
    WEISS, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) : 1131 - 1134
  • [16] REGULATION OF INTERLEUKIN-2 GENE ENHANCER ACTIVITY BY THE T-CELL ACCESSORY MOLECULE CD28
    FRASER, JD
    IRVING, BA
    CRABTREE, GR
    WEISS, A
    [J]. SCIENCE, 1991, 251 (4991) : 313 - 316
  • [17] FREEMAN GJ, 1989, J IMMUNOL, V143, P2714
  • [18] GRILLI M, IN PRESS INT REV CYT
  • [19] HOLSTI MA, 1989, J IMMUNOL, V143, P2514
  • [20] ACTIVATION OF THE MAP KINASE PATHWAY BY THE PROTEIN-KINASE RAF
    HOWE, LR
    LEEVERS, SJ
    GOMEZ, N
    NAKIELNY, S
    COHEN, P
    MARSHALL, CJ
    [J]. CELL, 1992, 71 (02) : 335 - 342