HOX GENE-EXPRESSION IN HUMAN SMALL-CELL LUNG CANCERS XENOGRAFTED INTO NUDE-MICE

被引:82
作者
TIBERIO, C
BARBA, P
MAGLI, MC
ARVELO, F
LECHEVALIER, T
POUPON, MF
CILLO, C
机构
[1] INT INST GENET & BIOPHYS,I-80125 NAPLES,ITALY
[2] INST CURIE,CNRS,URA 620,F-75005 PARIS,FRANCE
[3] INST GUSTAVE ROUSSY,F-94805 VILLEJUIF,FRANCE
关键词
D O I
10.1002/ijc.2910580426
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Transcription factors are crucial to an understanding of the molecular basis of neoplasia. Homeobox-containing genes are a family of transcriptional regulators encoding DNA-binding homeodomains, involved in the control of normal development. Class-1 human chromosomal organization, perhaps directly related to their function. Aberrant expression of homeobox-genes has been associated with both morphological abnormalities and oncogenesis. We have recently observed that alterations in HOX gene expression are detectable in kidney and colon cancer when compared to the corresponding normal organs. Here we have analyzed the expression of HOX genes in primary and metastatic human small-cell lung cancer (SCLC) xenografted in nude mice, in order to investigate whether HOX gene expression correlates with the histology and stage of SCLC progression. The results show that different SCLCs display differential patterns of HOX gene expression. Furthermore, in SCLC, the number of actively expressed HOX genes might be substantially lower in metastatic cancers than in primary tumors. The alteration in HOX gene expression in SCLCs mainly concerns the HOX B and C loci. This finding suggests that downregulation of HOX genes may play a role in small-cell lung cancer progression, possibly through their implication in tumor suppression. (C) 1994 Wiley-Liss, Inc.
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页码:608 / 615
页数:8
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