BIOSYNTHESIS OF INDOLEISOPROPIONIC ACID BY CLAVICEPS . BIOLOGICAL C-METHYLATION INVOLVING AN INTACT METHYL GROUP

被引：11

作者：

HORNEMANN, U

SPEEDIE, MK

KELLEY, KM

HURLEY, LH

FLOSS, HG

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1969年 / 131卷 / 02期

关键词：

D O I：

10.1016/0003-9861(69)90415-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(R)-Indoleisopropionic acid (I) [(2R)-(3-indolyl)-propionic acid], a metabolite of a Claviceps strain, is formed from l-tryptophan and the intact methyl group of l-methionine. Indoleacetic acid is not incorporated into indoleisopropionic acid. (2R,S), (3S,R)-3-methyltryptophan (β-methyltryptophan, isomer B) was efficiently incorporated, but no evidence for its formation by the organism could be obtained. A hypothetical scheme for the biosynthesis of indoleisopropionic acid is presented. © 1969.

引用

页码：430 / +

页数：1

共 38 条

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