BIOSYNTHESIS OF INDOLEISOPROPIONIC ACID BY CLAVICEPS . BIOLOGICAL C-METHYLATION INVOLVING AN INTACT METHYL GROUP

被引：11

作者：

HORNEMANN, U

SPEEDIE, MK

KELLEY, KM

HURLEY, LH

FLOSS, HG

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1969年 / 131卷 / 02期

关键词：

D O I：

10.1016/0003-9861(69)90415-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(R)-Indoleisopropionic acid (I) [(2R)-(3-indolyl)-propionic acid], a metabolite of a Claviceps strain, is formed from l-tryptophan and the intact methyl group of l-methionine. Indoleacetic acid is not incorporated into indoleisopropionic acid. (2R,S), (3S,R)-3-methyltryptophan (β-methyltryptophan, isomer B) was efficiently incorporated, but no evidence for its formation by the organism could be obtained. A hypothetical scheme for the biosynthesis of indoleisopropionic acid is presented. © 1969.

引用

页码：430 / +

页数：1

共 38 条

[11] STUDIES ON MECHANISM OF BIOLOGICAL CARBON ALKYLATION REACTIONS
JAUREGUI.G
LAW, JH
MCCLOSKE.JA
LEDERER, E
[J]. BIOCHEMISTRY, 1965, 4 (02) : 347 - +
[12] JAUREGUIBERRY G, 1964, CR HEBD ACAD SCI, V258, P3587
[13] JAUREGUIBERRY G., 1966, TETRAHEDRON, P27
[14] The consitutition-specificity of the hetero-auxins. 16. Announcement on the plant growth materials.
Kogl, F
Kostermans, DGFB
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1935, 235 : 201 - 216
[15] The antiposes of the a-(ss'indole)-propionacid and its different strengts physiological activity-38. Communication on plant growing agent(1))
Kogl, F
Verkaaik, B
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1944, 280 : 167 - 176
[16] A new auxin ("hetero-auxin") in urine. 11. Announcement on vegetable growth materials
Kogl, F
Haagen-Smit, AJ
Erxleben, H
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1934, 228 : 90 - 103
[17] LINGENS FRANZ, 1965, BIOCHIM BIOPHYSF ACTA, V107, P183, DOI 10.1016/0304-4165(65)90418-6
[18] MURRAY A, 1958, ORGANIC SYNTHESES IS, V1, P198
[19] PLIENINGER H, 1961, LIEBIGS ANN CHEM, V642, P214
[20] SCHACH, 1963, J AM CHEM SOC, V85, P3425

← 1 2 3 4 →