POSTTRANSCRIPTIONAL CONTROL OF GENE-EXPRESSION - BACTERIAL MESSENGER-RNA DEGRADATION

被引：8

作者：

ARRAIANO, CM

机构：

[1] Instituto de Tecnologia Quimica e Biológica (ITQB), Oeiras, 2780

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 1993年 / 9卷 / 04期

关键词：

MESSENGER RNA DEGRADATION; POSTTRANSCRIPTIONAL CONTROL; PROKARYOTES; RIBONUCLEASES;

D O I：

10.1007/BF00328030

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Many biological processes cannot be fully understood without detailed knowledge of RNA metabolism. The continuous breakdown and resynthesis of prokaryotic mRNA permit rapid production of new kinds of proteins. In this way, mRNA levels can regulate protein synthesis and cellular growth. Analysing mRNA degradation in prokaryotes has been particularly difficult because most mRNA undergo rapid exponential decay. Prokaryotic mRNAs differ in their susceptibility to degradation by endonucleases and exonucleases, possibly because of variation in their sequencing and structure. In spite of numerous studies, details of mRNA degradation are still largely unknown. This review highlights those aspects of mRNA metabolism which seem most influential in the regulation of gene expression.

引用

页码：421 / 432

页数：12

共 105 条

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