A STRUCTURALLY FLEXIBLE AND ANTIGENICALLY VARIABLE N-TERMINAL DOMAIN OF THE HEPATITIS-C VIRUS E2/NS1 PROTEIN - IMPLICATION FOR AN ESCAPE FROM ANTIBODY

被引:160
作者
TANIGUCHI, S
OKAMOTO, H
SAKAMOTO, M
KOJIMA, M
TSUDA, F
TANAKA, T
MUNEKATA, E
MUCHMORE, EE
PETERSON, DA
MISHIRO, S
机构
[1] INST IMMUNOL,KORAKU 1-1-10,BUNKYO KU,TOKYO 112,JAPAN
[2] NYU MED CTR,LEMSIP,NEW YORK,NY 10987
[3] UNIV TSUKUBA,INST APPL BIOCHEM,TSUKUBA,IBARAKI 305,JAPAN
[4] JICHI MED SCH,DIV IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
[5] UNIV TSUKUBA,SCH MED,DEPT INTERNAL MED,TSUKUBA,IBARAKI 305,JAPAN
[6] YAMANASHI MED COLL,DEPT INTERNAL MED 1,YAMANASHI 40938,JAPAN
[7] VIRAL HEPATITIS RES FDN JAPAN,TOKYO 113,JAPAN
[8] JAPANESE RED CROSS BLOOD CTR,SAITAMA 338,JAPAN
[9] ABBOTT LABS,ABBOTT PK,IL 60064
关键词
D O I
10.1006/viro.1993.1378
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hepatitis C virus persists in most infected hosts, and causes chronic hepatitis, liver cirrhosis, and/or hepatocellular carcinoma in humans. During the infection the RNA genome of hepatitis C virus undergoes frequent missense mutations at one or two‗hypervariable‘regions within a presumptive envelope gene (Okamoto et al., 1992, Virology 190, 894-899; Ogata et al., 1991, Proc. Natl. Acad. Sci. USA 88, 3392-3396). In the present study, we analyzed three cases of hepatitis C virus infection, two in chimpanzees and one in humans, for the antigenicity of peptides predicted from the hypervariable region of viral RNA obtained during the follow-up. Our results showed a successive appearance of hepatitis C virus mutants with antigenically distinct amino acid sequence within the domain; and the amino acid replacement was associated with an alteration of predicted local secondary structure of the epitope region. Hence, the hypervariable domain of the hepatitis C virus envelope appeared to be structurally flexible and antigenically variable, providing the virus a way to escape from host immunity. © 1993 American Health Foundation and Academic Press.
引用
收藏
页码:297 / 301
页数:5
相关论文
共 11 条
  • [1] LACK OF PROTECTIVE IMMUNITY AGAINST REINFECTION WITH HEPATITIS-C VIRUS
    FARCI, P
    ALTER, HJ
    GOVINDARAJAN, S
    WONG, DC
    ENGLE, R
    LESNIEWSKI, RR
    MUSHAHWAR, IK
    DESAI, SM
    MILLER, RH
    OGATA, N
    PURCELL, RH
    [J]. SCIENCE, 1992, 258 (5079) : 135 - 140
  • [2] ANALYSIS OF ACCURACY AND IMPLICATIONS OF SIMPLE METHODS FOR PREDICTING SECONDARY STRUCTURE OF GLOBULAR PROTEINS
    GARNIER, J
    OSGUTHORPE, DJ
    ROBSON, B
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) : 97 - 120
  • [3] HYPERVARIABLE REGIONS IN THE PUTATIVE GLYCOPROTEIN OF HEPATITIS-C VIRUS
    HIJIKATA, M
    KATO, N
    OOTSUYAMA, Y
    NAKAGAWA, M
    OHKOSHI, S
    SHIMOTOHNO, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (01) : 220 - 228
  • [4] SUPPRESSION OF HEPATITIS-C VIRUS-RNA BY INTERFERON-ALPHA
    KANAI, K
    IWATA, K
    NAKAO, K
    KAKO, M
    OKAMOTO, H
    [J]. LANCET, 1990, 336 (8709) : 245 - 245
  • [5] HCV GENOTYPES IN CHRONIC HEPATITIS-C AND RESPONSE TO INTERFERON
    KANAI, K
    KAKO, M
    OKAMOTO, H
    [J]. LANCET, 1992, 339 (8808) : 1543 - 1543
  • [6] NUCLEOTIDE-SEQUENCE AND MUTATION-RATE OF THE H-STRAIN OF HEPATITIS-C VIRUS
    OGATA, N
    ALTER, HJ
    MILLER, RH
    PURCELL, RH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) : 3392 - 3396
  • [7] THE DEGREE OF VARIABILITY IN THE AMINO TERMINAL REGION OF THE E2/NS1 PROTEIN OF HEPATITIS-C VIRUS CORRELATES WITH RESPONSIVENESS TO INTERFERON THERAPY IN VIREMIC PATIENTS
    OKADA, S
    AKAHANE, Y
    SUZUKI, H
    OKAMOTO, H
    MISHIRO, S
    [J]. HEPATOLOGY, 1992, 16 (03) : 619 - 624
  • [8] OKAMOTO H, 1990, JPN J EXP MED, V60, P215
  • [9] GENETIC DRIFT OF HEPATITIS-C VIRUS DURING AN 8.2-YEAR INFECTION IN A CHIMPANZEE - VARIABILITY AND STABILITY
    OKAMOTO, H
    KOJIMA, M
    OKADA, SI
    YOSHIZAWA, H
    IIZUKA, H
    TANAKA, T
    MUCHMORE, EE
    PETERSON, DA
    ITO, Y
    MISHIRO, S
    [J]. VIROLOGY, 1992, 190 (02) : 894 - 899
  • [10] THOMAS JP, 1988, P NATL ACAD SCI USA, V85, P1932