TUMOR SUPPRESSOR GENES

被引：6

作者：

LEE, NK

机构：

[1] Department of Otolaryngology-Head and Neck Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 1992年 / 14卷 / 05期

关键词：

D O I：

10.1002/hed.2880140513

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Tumor suppressor genes are negative regulators of cell growth. When their normal function is compromised, absence of their inhibitory effects can lead to unrestrained cell cycling and growth. Strong evidence now confirms that loss of proper function of these genes is a common occurrence leading to cancer. Their failure can be caused by alterations in the gene DNA or malfunction of their protein products. The recent extraordinary accumulation of knowledge about these genes reveals that normal carcinogenesis represents breakdown of normal regulatory processes.

引用

页码：407 / 414

页数：8

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