EVOLVING ROLE OF GONADOTROPIN-RELEASING-HORMONE ANTAGONISTS

被引：19

作者：

GORDON, K

HODGEN, GD

机构：

[1] Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 07期

关键词：

D O I：

10.1016/1043-2760(92)90128-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GnRH antagonists, unlike GnRH agonists, do not act via "downregulation." Instead, GnRH antagonists monopolize the GnRH receptors to such an extent that endogenous GnRH is unable to bind to sufficient numbers of GnRH receptors to provoke release of LH/FSH. This fundamental difference in the mechanism of action of GnRH antagonists versus GnRH agonists is anticipated to result in clinical benefits for certain applications.

引用

页码：259 / 263

页数：5

共 49 条

[1]

ABBASI R, 1986, JAMA-J AM MED ASSOC, V255, P1600

[2] CLINICAL-APPLICATIONS OF GNRH AND ITS ANALOGS [J].

BARBIERI, RL .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1992, 3 (01) :30-34

[3] HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE [J].

BELCHETZ, PE ;

PLANT, TM ;

NAKAI, Y ;

KEOGH, EJ ;

KNOBIL, E .

SCIENCE, 1978, 202 (4368) :631-633

[4] GONADOTROPIN-RELEASING HORMONE STIMULATION OF LUTEINIZING-HORMONE RELEASE - A LIGAND-RECEPTOR-EFFECTOR MODEL [J].

BLUM, JJ ;

CONN, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (23) :7307-7311

[5]

BOUCHARD P, 1990, RECENT PROGRESS ON GNRH AND GONADAL PEPTIDES, P209

[6] GONADOTROPIN-RELEASING-HORMONE ANTAGONIST PLUS TESTOSTERONE - A POTENTIAL MALE CONTRACEPTIVE [J].

BREMNER, WJ ;

BAGATELL, CJ ;

STEINER, RA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (03) :465-469

[7] PRIMARY STRUCTURE OF OVINE HYPOTHALAMIC LUTEINIZING HORMONE-RELEASING FACTOR (LRF) [J].

BURGUS, R ;

BUTCHER, M ;

AMOSS, M ;

BLACKWELL, R ;

VALE, W ;

LING, N ;

RIVIER, J ;

MONAHAN, M ;

FELLOWS, R ;

GUILLEMIN, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (01) :278-+

[8] CALCIUM SIGNALING AND GONADOTROPIN-SECRETION [J].

CATT, KJ ;

STOJILKOVIC, SS .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1989, 1 (01) :15-20

[9]

CHANG JP, 1986, J BIOL CHEM, V261, P9105

[10]

CHILLIK CF, 1987, FERTIL STERIL, V48, P480

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