EVOLVING ROLE OF GONADOTROPIN-RELEASING-HORMONE ANTAGONISTS

被引：19

作者：

GORDON, K

HODGEN, GD

机构：

[1] Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 07期

关键词：

D O I：

10.1016/1043-2760(92)90128-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GnRH antagonists, unlike GnRH agonists, do not act via "downregulation." Instead, GnRH antagonists monopolize the GnRH receptors to such an extent that endogenous GnRH is unable to bind to sufficient numbers of GnRH receptors to provoke release of LH/FSH. This fundamental difference in the mechanism of action of GnRH antagonists versus GnRH agonists is anticipated to result in clinical benefits for certain applications.

引用

页码：259 / 263

页数：5

共 49 条

[11] MECHANISM OF GNRH ACTION IN GONADOTROPHS [J].

CLAYTON, RN .

HUMAN REPRODUCTION, 1988, 3 (04) :479-483

[12] GONADOTROPIN-RELEASING HORMONE RECEPTORS - CHARACTERIZATION, PHYSIOLOGICAL REGULATION, AND RELATIONSHIP TO REPRODUCTIVE FUNCTION [J].

CLAYTON, RN ;

CATT, KJ .

ENDOCRINE REVIEWS, 1981, 2 (02) :186-209

[13] CONVERSION OF A GONADOTROPIN-RELEASING HORMONE ANTAGONIST TO AN AGONIST [J].

CONN, PM ;

ROGERS, DC ;

STEWART, JM ;

NIEDEL, J ;

SHEFFIELD, T .

NATURE, 1982, 296 (5858) :653-655

[14] PEPTIDE ANTAGONISTS OF LH-RH - LARGE INCREASES IN ANTI-OVULATORY ACTIVITIES PRODUCED BY BASIC D-AMINO ACIDS IN THE 6 POSITION [J].

COY, DH ;

HORVATH, A ;

NEKOLA, MV ;

COY, EJ ;

ERCHEGYI, J ;

SCHALLY, AV .

ENDOCRINOLOGY, 1982, 110 (04) :1445-1447

[15] SIMULATION OF THE NORMAL MENSTRUAL-CYCLE IN KALLMAN SYNDROME BY PULSATILE ADMINISTRATION OF LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) [J].

CROWLEY, WF ;

MCARTHUR, JW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 51 (01) :173-175

[16]

DAHL KD, 1986, J CLIN ENDOCR METAB, V63, P792

[17]

DANFORTH DR, 1989, P SERONO S MENOPAUSE, P17

[18] LHRH ANALOGS - THEIR CLINICAL PHYSIOLOGY AND DELIVERY SYSTEMS [J].

FRASER, HM .

BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY, 1988, 2 (03) :639-658

[19] SUPPRESSION OF OVARIAN ESTRADIOL SECRETION BY A SINGLE INJECTION OF ANTIDE IN CYNOMOLGUS MONKEYS DURING THE EARLY FOLLICULAR PHASE - IMMEDIATE, SUSTAINED, AND REVERSIBLE ACTIONS [J].

GORDON, K ;

WILLIAMS, RF ;

DANFORTH, DR ;

CONN, PM ;

HUTCHISON, JS ;

HODGEN, GD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (06) :1262-1268

[20] ANTIDE-INDUCED SUPPRESSION OF PITUITARY GONADOTROPIN AND OVARIAN-STEROID SECRETION IN CYNOMOLGUS MONKEYS - PREMATURE LUTEOLYSIS AND PROLONGED INHIBITION OF FOLLICULOGENESIS FOLLOWING SINGLE TREATMENT [J].

GORDON, K ;

WILLIAMS, RF ;

DANFORTH, DR ;

HODGEN, GD .

BIOLOGY OF REPRODUCTION, 1991, 44 (04) :701-706

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