PEPTIDE NUCLEIC-ACID (PNA) WITH A CHIRAL BACKBONE BASED ON ALANINE

被引：70

作者：

DUEHOLM, KL

PETERSEN, KH

JENSEN, DK

EGHOLM, M

NIELSEN, PE

BUCHARDT, O

机构：

[1] UNIV COPENHAGEN,HC ORSTED INST,MED BIOTECHNOL RES CTR,DK-2100 COPENHAGEN O,DENMARK

[2] UNIV COPENHAGEN,PANUM INST,DEPT BIOCHEM B,MED BIOTECHNOL RES CTR,DK-2200 COPENHAGEN N,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)80684-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthesis of N-(2-Boc-aminoethyl)-N-(thymin-1-ylacetyl)aline (5) is presented. It is demonstrated that chiral integrity can be preserved. PNA (Peptide Nucleic Acid) containing the D-form of 5 hybridizes to complementary DNA with higher affinity than PNA containing the L-form of 5.

引用

页码：1077 / 1080

页数：4

共 15 条

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